Is a hypothermic effect of LY300164, valproate and phenobarbital evident in mice?
Świader MJ, Łuszczki JJ, Zwolan A, Wierzchowska-Cioch E, Wielosz M, Czuczwar SJ

Purpose: The aim of this study was to evaluate the influence of LY300164 (an AMPA/kainate receptor antagonist) administered alone or in combination with valproate (VPA) or phenobarbital (PB) on body temperature in mice. 
Material and methods: The temperature measurements were performed in Albino Swiss mice injected with the respective drugs by using a rectal thermistor thermometer.
Results: LY300164, at the dose of 2 mg/kg, did not affect the body temperature of the examined animals. However, the combination of LY300164 (2 mg/kg) with VPA (165 mg/kg) resulted in a significant decrease in body temperature within 60-180 min after their peak of maximum anticonvulsant activity. Moreover, VPA (269 mg/kg) administered alone, evidently produced  hypothermic effects at the times between 120-180 min after the peak of the maximum antiseizure effect. In contrast, phenobarbital administered alone or in combination with LY300164 did not affect the body temperature in the mice.
Conclusions: Hypothermia induced by LY 300164 combined with VPA may be useful in various central nervous system disease treatments. 

Key words:   temperature monitoring, hypothermia, LY300164, valproate, phenobarbital.